The Underlying Causes of Erectile Dysfunction
from Family Medicine Net Guide Vol. 1, No. 2 (December,
2003)
Men are typically more reluctant to visit the doctor than
women, and then it’s only for basic things such as checkups
and minor aches and ailments. When it comes to the subject
of erectile dysfunction (ED), men are notoriously reticent.
Whether they are uncomfortable discussing this condition with
their doctors and sexual partners due to lack of knowledge,
feelings of inadequacy, the perception that they are being
judged, or any of a number of other reasons, it's unfortunate.
Especially since many medical breakthroughs have been made
in the last few years so that most men suffering from ED can
receive treatment that allows them to lead normal, healthy
sex lives.
It all starts with communication, though, especially with
a spouse or partner. Often, the best facilitator of effective
communication is information. This article is intended to
provide men and their partners with the facts on ED, including
how it is defined, what causes it, how it’s diagnosed, and
how it’s treated. And, since the affected man’s partner has
just as much at stake, and can often be the means to get the
man to go see his doctor.
ED Defined Erectile dysfunction can be defined
as “the repeated inability to get or keep an erection firm
enough for sexual intercourse.” It can be characterized by
the “total inability to achieve erection, an inconsistent
ability to do so, or a tendency to sustain only brief erections.”
The National Kidney and Urologic Diseases Information Clearinghouse
(NKUDIC) estimates that 5% of 40-year-old men, and between
15%-25% of men 65 years old and older, experience ED.
Often men never receive treatment because they're reluctant
to discuss the subject with their doctor. Until recently,
it was believed that the cause of ED was psychological; however,
it’s now understood that in at least 75% of cases, it is a
symptom of, or caused by, an underlying physical condition.
How Do I Know If I Have ED? This site, from
the University
of Maryland Medicine, offers a helpful list of ways in
which your physician can determine whether a patient is suffering
from erectile dysfunction, noting that a “physician typically
interviews the patient about many physical and psychological
factors. The patient must be as frank as possible for his
physician to make a diagnosis. He should not interpret these
questions as pushy or too personal if he expects to obtain
help. These questions are very relevant and important for
determining the proper approach. Even when there is a clear
physical cause for ED, relationships and psychological factors
can also have an effect.”
The initial exam involves a medical and personal history
that covers past and present medical problems, medications
currently being taken, other factors, and sexual history which
can help in determining the nature of the dysfunction by inquiring
as to the frequency, quality, and duration of the patient’s
erections, the specific circumstances when erectile dysfunctions
occur, and other relevant details. The physician will also
interview the patient’s sexual partner, as doing so “may help
the physician to better decipher underlying causes and in
turn better recommend treatment choices.”
Next is the physical exam including a study the patient’s
genital area to determine the degree of response to physical
stimulation (diminished or absent response could indicate
a nervous component to ED), and also to check for prostate
abnormalities. A physician may prescribe several laboratory
tests to determine the nature and cause of a patient’s ED,
including blood tests for hormonal imbalances and tests for
other medical conditions that may be causing or contributing
to ED (hypertension, diabetes, etc). Less invasive diagnostic
methods include monitoring the frequency and duration of night-time
erections (helpful in determining if ED has a psychological
component), and measuring the penile brachial index (compares
blood pressure in the penis with the blood pressure taken
in the arm; useful in detecting decreased blood flow to the
penis).
What Causes ED? The majority of ED cases
is caused either by an underlying physical disorder or disease,
or develops as a side effect of a medication the patient is
taking. This link
explains that “impotence occurs when there is a problem with
any of the systems needed to get or maintain an erection.
The good news is that potency can usually be restored when
a man is treated for underlying medical conditions.”
A common cause of ED is vascular disease; hardening of the
arteries can affect the artery leading to the penis so that
it cannot dilate enough to deliver enough blood to produce
an erection. A second cause is diabetes; nearly one in every
four men with ED has diabetes. The nerve deterioration and
damage to blood vessels that often accompanies diabetes can
also cause erectile dysfunction. Similarly, diseases that
affect the nervous system, including Parkinson’s disease and
multiple sclerosis, often play a role in this problem. ED
can also be caused by surgery for cancer of the prostate,
colon, bladder, or rectum since it's possible for the nerves
and blood vessels that control erections to be damaged in
the process of removing cancerous tissue (surgery for cancer
of the prostate frequently results in ED of some severity).
Other diseases and conditions that can cause ED include kidney
disease, hypertension, and several neurological disorders.
Injury and trauma can also play a part in ED. The nerve
supply to the penis is very delicate and complicated. A proper
conduction of impulses along these is basic for the initiation
and maintenance of an erection. It is these nerves that activate
the arteries and the veins and alter the dynamics of blood
flow within them.” Trauma or injury to the penis, spinal cord,
pelvis, prostate, or bladder can result in damage to the nerves,
blood vessels, and other tissues involved with blood flow
to the penis,sending and relaying nerve signals associated
with physical stimulation, and maintaining an erection.
Other possible factors in ED:
- A side effect of many prescription and over-the-counter
medications
- Psychological and emotional factors, such as stress, anxiety,
depression, and other mental triggers
- Smoking
- Inadequate levels of testosterone
- Alcoholism or alcohol abuse
Treating ED
Medical professionals prefer to treat ED in stages, beginning
with the least invasive methods first. Often the first step
is to reduce the dosage of or eliminate entirely any prescription
or over-thecounter medications that are known to cause or
contribute to ED. Another treatment method is to devise a
plan to reduce the stress and anxiety that can cause ED through
the use of behavioral modification. But, as ED is most commonly
caused by a physical disorder, treatment with oral medications
is likely. This is the form of remedy that gets the most play
in the media and is likely on the minds of many patients.
Viagra (http://www.viagra.com/) is the best known prescription
medication for ED, first approved in 1998 and since prescribed
to millions of men. Viagra works by increasing blood flow
to the penis and should be taken approximately one hour prior
to expected sexual activity; its effects persist for at least
four hours. It is important to note that Viagra, contrary
to a common misperception, is not an aphrodisiac and does
not automatically cause erections; sexual excitement is still
necessary for the patient to achieve an erection. Men taking
nitrate-based medications, such as nitroglycerine for a heart
condition, are advised not to use this form of therapy. Viagra's
side effects can include headache, indigestion, facial flushing,
and "blue vision" (basically just what it sounds like).
The recently approved medication Levitra (http://www.levitra.com/) is similar to Viagra; patients
should take Levitra about an hour before sexual activity and-just
as with Viagra-require some form of sexual stimulation to
achieve erection. The most common side effects with Levitra
are headache, flushing, stuffy or runny nose, indigestion,
upset stomach, or dizziness.
A third drug, Cialis (http://www.cialisnews.com/cialis/cialis_info.asp), may
also soon be approved and on the market. Cialis is differentiated
from the other two ED medications by its longer-lasting effects
(it has already earned the nickname "The Weekend Pill" in
Europe, where it is already on the market). Side effects from
Cialis are reported as similar to Viagra and Levitra, though
some patients have also reported experiencing muscle aches
and pain.
This site (http://rxcialis.com/compare.html) contains a chart offering
a quick comparison of these three drugs. A fourth medication,
Uprima, already approved in the UK and parts of Europe, may
also be close to approval here in the US. It is a more rapid-acting
ED medication that may centrally affect the brain to trigger
an erection. There are also drugs available that can produce
erections when they are injected into the penis, including
papaverine hydrochloride, phentolamine, and alprostadil. These
medications work by widening blood vessels, causing the penis
to become engorged with blood,
but may also "create unwanted side effects, however, including
persistent erection (known as priapism) and scarring."
Other remedies available for men with erectile dysfunction
who do not respond to medication therapy include several mechanical
or prosthetic devices. One such option is an external vacuum
pump device that draws blood into the penis by creating a
partial vacuum and then, through the use of an elastic band,
maintains the erection by preventing blood from flowing back
out of the penis. Many men and their partners find this external
prosthetic too bulky. In this case, a surgically implanted
internal prosthesis may be more appealing.
There are two varieties: "malleable" implants consisting
of twin rods that must be manually adjusted, and inflatable
implants that use surgically-inserted cylinders filled with
pressurized fluid by means of a small pump usually located
under the scrotum (both the pump and fluid reservoir are also
surgically implanted). And finally, there exist surgical procedures
to repair obstructed arteries (penile arterial revascularization)
that could cause ED, and also a procedure that intentionally
blocks off veins that allow blood to exit the penis (venous
ligation surgery), reducing blood leakage that diminishes
the rigidity of the patient's erection. There are questions,
however, regarding the safety and long-term effectiveness
of this rarely performed procedure.
As you can see medical science has learned a great deal about
the causes, diagnosis, and treatment of erectile dysfunction.
Patients no longer need resign themselves to the "fact" that
this condition is an unavoidable part of the aging process,
or that there is nothing that can be done about it. The most
important part of dealing with ED is communication, both between
patients and their physicians and between patients and their
partners. Through openness and honesty, men and their partners
can reduce much of the fear, stress, and anxiety that often
accompany ED, and, under a physician's care, begin treatment
that will allow them to restore their sex life. |